Molecular mass determination for prostate-specific antigen and α1-antichymotrypsin complexed in vitro
✍ Scribed by William D. Bedzyk; Barbara Larsen; Steve Gutteridge; Robert A. Ballas
- Book ID
- 111138375
- Publisher
- Portland Press
- Year
- 1998
- Tongue
- English
- Weight
- 323 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0885-4513
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Background. Prostate specific antigen (PSA) is a zymogen of a 33-kilodalton (kD) serine proteinase with extensive similarity to glandular kallikreins. The mechanism responsible for converting the zymogen into active proteinase has not been defined, but active PSA may be irreversibly inactivated in v
## BACKGROUND. Complexes between prostate-specific antigen (PSA) and ␣ 1 -protease inhibitor (API) occur in serum and they are of potential interest in the diagnosis of prostate cancer. Pure PSA-API complexes are needed for development of specific assays, but complex formation has not earlier been