## Abstract Silencing of tumor suppressor genes (TSGs), by DNA methylation, is well known in adult cancers. However, based on the βstem cellβ theory of tumorigenesis, the early epigenetic events arising in malignant precursors remain unknown. A recent report1 demonstrates that, while pluripotent em
β¦ LIBER β¦
Molecular marks for epigenetic identification of developmental and cancer stem cells
β Scribed by Samir Kumar Patra; Moonmoon Deb; Aditi Patra
- Book ID
- 107687360
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 631 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1868-7075
No coin nor oath required. For personal study only.
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## Abstract Molecularβtargeted therapy is a hopeful approach for pancreatic cancer. Silencing of tumor suppressor genes can occur by histone deacetylation and/or DNA methylation in the promoter. Here, we identified epigenetically silenced genes in pancreatic cancer cells. Pancreatic cancer cell lin