Target genes implicated in cellular transformation and tumor progression have been divided into two categories: proto-oncogenes which, when activated, become dominant events characterized by the gain of function, and tumor suppressor genes which become recessive events characterized by the loss of f
Molecular markers for detection, surveillance and prognostication of bladder cancer
β Scribed by Olaf PJ Vrooman; J Alfred Witjes
- Book ID
- 108977898
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 122 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0919-8172
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Bladder cancer i s the result of a clonal expansion of cancer cells in which multiple genetic alterations have accumulated. Point mutations of the p53 gene are frequently observed in bladder cancer. Loss of a retinoblastoma (Rb) allele is also common in bladder cancer. Recent data have shown frequen
Transitional cell carcinoma (TCC) is the most common bladder tumor and approximately 90% of bladder TCC are superficial at initial diagnosis. High recurrence rate and possible progression to muscle invasive disease that is eventually indicated for radical cystectomy are established features of these