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Molecular Information Defines a New Entity of Hereditary Colorectal Cancer

โœ Scribed by Rodrigo Jover; Antoni Castells


Book ID
119760241
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
72 KB
Volume
134
Category
Article
ISSN
0016-5085

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Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common hereditary form of colorectal carcinoma (CRC) and may account for 5-10% of the total CRC burden. The discovery of DNA mismatch repair (MMR) genes, inclusive of hMSH2, hMLH1, hPMS2, and hMSH6, has enabled the identification of wh