Molecular imprinting targeted for α-tocopherol by calix[4]resorcarenes derivative in membrane scaffold prepared by phase inversion

✍ Scribed by Che Ku M. Faizal; Yasuaki Kikuchi; Takaomi Kobayashi

• Book ID: 104055897
• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 541 KB
• Volume: 334
• Category: Article
• ISSN: 0376-7388
• DOI: 10.1016/j.memsci.2009.02.019

✦ Synopsis

A molecular imprinting polymer targeted to ␣-tocopherol (␣-Toc) was developed by polymer membrane scaffold method containing calix[4]resorcarenes and showing multiple non-covalent interactions with the template. A host-guest complex was fixed in a scaffold polymer membrane consisting of polysulfone. Phase inversion of the polymer solution containing the host-guest complex was carried out from a NMP solution into water. After the membrane was formed, removal of the template was performed by treating with MeOH/AcOH solution. It was observed that the amount of ␣-Toc bound to the imprinted and non-imprinted membranes in methanol/water (2:1, v/v%) was 41.1 ± 0.9 and 22.2 ± 1.1 mol/gmembrane, respectively. Relative to the ␣-Toc analogues, 2-napthol (2-Nap), permselective experiments were achieved with a separation factor of 14.5 for ␣-Toc retained.