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Molecular imprinting of the endogenous neuropeptide Leu5-enkephalin and some derivatives thereof

✍ Scribed by Lars I. Andersson; Ralf Müller; Klaus Mosbach

Book ID: 102491840
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 383 KB
Volume: 17
Category: Article
ISSN: 1022-1336
DOI: 10.1002/marc.1996.030170110

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✦ Synopsis

Abstract

We have undertaken the molecular imprinting of Leu^5^‐enkephalin, and derivatives related to this endogenous neuropeptide, in highly cross‐linked methacrylic acid/ethylene dimethacrylate copolymers. The underivatized enkephalin peptide yielded polymers with poor recognition abilities, since the imprinting of this compound had to be performed using dimethyl sulfoxide, which was found to interfere with the imprint inducement, as the solvent of polymerisation. In order to circumvent this problem, the amino‐ and carboxy‐protected derivatives Boc‐Leu^5^‐enkephalin and Leu^5^‐enkephalin anilide, which are soluble in apolar solvents, were investigated as alternative imprint molecules. Both compounds led to polymers which are highly specific for the imprint species. The anilide derivative was shown to be a good substitute for the free peptide since the resultant polymers showed efficient recognition of the parent enkephalin structure.

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