Molecular Imaging: Radiopharmaceuticals for PET and SPECT

✍ Scribed by Shankar Vallabhajosula (auth.)

Publisher: Springer Berlin Heidelberg
Year: 2009
Tongue: English
Leaves: 379
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

✦ Table of Contents

Front Matter....Pages i-xix
Molecular Imaging: Introduction....Pages 1-9
Science of Atomism: A Brief History....Pages 11-23
Atoms and Radiation....Pages 25-34
Radioactivity....Pages 35-43
Production of Radionuclides....Pages 45-58
PET and SPECT Scanners....Pages 59-82
Chemistry: Basic Principles....Pages 83-107
Cell and Molecular Biology....Pages 109-132
Radiopharmaceuticals....Pages 133-149
Chemistry of Radiohalogens (F, Br. and I)....Pages 151-166
Chemistry of Organic Radionuclides (C, N, and O)....Pages 167-177
Chemistry of Metal Radionuclides (Rb, Ga, In, Y, Cu and Tc)....Pages 179-196
Qouality Control of PET Rediopharmaceuticals....Pages 197-204
Pharmacokinetics and Modeling....Pages 205-214
Molecular Imaging in Oncology....Pages 215-254
Molecular Imaging in Neurology and Psychiatry....Pages 255-298
Molecular Imaging in Cardiology....Pages 299-323
Molecular Imaging of Gene Expression and Cell Trafficking....Pages 325-338
Radiation Dosimetry and Protection....Pages 339-349
Radiopharmaceuticals: Drug Development and Regulatory Issues....Pages 351-361
Back Matter....Pages 363-371

✦ Subjects

Nuclear Medicine; Imaging / Radiology; Oncology; Cardiology; Neurology

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