✦ LIBER ✦

Molecular identity, synaptic localization, and physiology of calcium channels in retinal bipolar cells

✍ Scribed by Amy Berntson; W. Rowland Taylor; Catherine W. Morgans

Book ID: 102382215
Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 197 KB
Volume: 71
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.10459

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✦ Synopsis

Bipolar cells convey information through the retina via graded changes in their membrane potential and modulate transmitter release through the influx of calcium via L-type calcium channels. However, the molecular identity of the alpha(1) subunit has not been confirmed. We report the presence of the newly cloned alpha(1F) subunit in mouse bipolar cell synaptic terminals. The alpha(1F) subunits are localized to hot spots, possibly corresponding to active zones. We also report the physiological properties of two calcium currents present in mouse bipolar cells, a low-voltage-activated L-type current and a low-voltage-activated T-type calcium current. The physiological properties of the T-type current suggest that it is completely inactivated under physiological conditions. The L-type current may be mediated by the alpha(1F) subunit, and influx of calcium through the alpha(1F) channel may control neurotransmitter release from the bipolar cell terminal.

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