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Molecular hydrogen suppresses FcεRI-mediated signal transduction and prevents degranulation of mast cells

✍ Scribed by Tomohiro Itoh; Yasunori Fujita; Mikako Ito; Akio Masuda; Kinji Ohno; Masatoshi Ichihara; Toshio Kojima; Yoshinori Nozawa; Masafumi Ito

Book ID
116299215
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
902 KB
Volume
389
Category
Article
ISSN
0006-291X

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✍ Yoshimichi Okayama; Christine Tkaczyk; Dean D. Metcalfe; Alasdair M. Gilfillan 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 318 KB

## Abstract We have demonstrated that CD34^+^ IFN‐γ‐treated human mast cells (HuMC) express functional FcγRI and that aggregation of these receptors leads to mediator release. As the signaling pathways linking FcγRI aggregation to mediator release are unknown, we examined FcγRI‐dependent activation