Molecular heterogeneity of complement component c4-null and 21-hydroxylase genes in systemic lupus erythematosus
β Scribed by Rose Goldstein; Frank C. Arnett; Robert H. Mclean; Wilma B. Bias; Madeleine Duvic
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 879 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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## Abstract ## Objective C4βderived activation fragments are the only complement ligands present on the surfaces of normal erythrocytes. The significance of this observation is unknown, and the role of erythrocyteβbound C4 (EβC4) in human disease has not been explored. More than any other human di
## Abstract Systemic lupus erythematosus (SLE), an autoimmune disease characterized by chronic nephritis, arthritis and dermatitis, and the presence of antinuclear autoantibodies, is associated with complement factor deficiencies in the classical activation pathway. In addition, IFNβΞ± seems to be a
## Abstract We studied 31 children with systemic lupus erythematosus (SLE) and 108 firstβdegree relatives of the children to determine if HLA type, familial relationship to patient, or gender influenced the familial aggregation of SLE and the serologic and serum complement abnormalities associated