Mutation/deletion of the adenomatous polyposis coli (APC) tumor suppressor gene in germline cells of rodents and humans is associated with increased intestinal activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, and intestinal neoplasia. To study the role of APC in si
Molecular genetics of ornithine decarboxylase in human tumor cells
✍ Scribed by Juhani Jänne; Leena Alhonen; Ari Hirvonen; Jarmo Wahlfors
- Book ID
- 118372107
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 603 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0065-2571
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The activity of the polyamine biosynthetic enzyme, ornithine decarboxylase (ODC), has been shown to be rapidly modulated by a variety of growth regulatory molecules. In this report the effect of the growth modulatory peptide, tumor necrosis factor, on ODC activity was examined on two cell lines whic
A human ornithine decarboxylase (ODC) gene probe has been isolated from a Jurkat T-cell cDNA expression library, sequenced, and used to analyze ODC mRNA levels in untransformed human lymphocytes and fibroblasts stimulated to proliferate by various mitogens. The partial cDNA sequence is 86% homologou