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Molecular genetics of hereditary nonpolyposis colorectal cancer; basic research with clinical applications

✍ Scribed by L.A. Aaltonen


Book ID
114136442
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
97 KB
Volume
91
Category
Article
ISSN
0165-4608

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Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common hereditary form of colorectal carcinoma (CRC) and may account for 5-10% of the total CRC burden. The discovery of DNA mismatch repair (MMR) genes, inclusive of hMSH2, hMLH1, hPMS2, and hMSH6, has enabled the identification of wh

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## BACKGROUND. The hereditary nonpolyposis colorectal carcinoma (HNPCC) syndrome is an autosomal dominant genetic disorder caused by the inheritance of a mutation in one of a family of genes encoding DNA mismatch repair (MMR) proteins. HNPCC manifests as genetic instability in linked tumors. Clini