Molecular genetics of hereditary nonpolyposis colorectal cancer; basic research with clinical applications
β Scribed by L.A. Aaltonen
- Book ID
- 114136442
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 97 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0165-4608
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Lynch syndrome, or hereditary nonpolyposis colon cancer (HNPCC), is an autosomaldominant disease accounting for approximately 1 5 % of all colorectal cancer cases. Due to the lack of pathognomonic morphological or biomolecular markers, HNPCC has traditionally posed unique problems to clinicians and
Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common hereditary form of colorectal carcinoma (CRC) and may account for 5-10% of the total CRC burden. The discovery of DNA mismatch repair (MMR) genes, inclusive of hMSH2, hMLH1, hPMS2, and hMSH6, has enabled the identification of wh
## BACKGROUND. The hereditary nonpolyposis colorectal carcinoma (HNPCC) syndrome is an autosomal dominant genetic disorder caused by the inheritance of a mutation in one of a family of genes encoding DNA mismatch repair (MMR) proteins. HNPCC manifests as genetic instability in linked tumors. Clini