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Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC

✍ Scribed by Karin Frank-Raue; Susanne Rondot; Friedhelm Raue

Book ID
116734724
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
537 KB
Volume
322
Category
Article
ISSN
0303-7207

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## Abstract Cancer cells require large amounts of micronutrients, particularly iron, for their rapid growth and frequent divisions. Cellular iron uptake is regulated by the transferrin receptor and the hemochromatosis protein (HFE) system. Two frequent mutations in the __HFE__ gene, H63D and C282Y,