Molecular genetic studies of early breast cancer evolution
β Scribed by Peter O'Connell; Vladimir Pekkel; Suzanne Fuqua; C. Kent Osborne; D. Craig Allred
- Publisher
- Springer US
- Year
- 1994
- Tongue
- English
- Weight
- 778 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
It is clear that breast cancer progression is associated with inactivation of a number of different recessive oncogenes. The most widely evaluated tumor suppressor gene, p53, is mutated in approximately 30-50% of sporadic breast cancers. Mutations usually occur early in malignant progression. Loss o
Target genes implicated in cellular transformation and tumor progression have been divided into two categories: proto-oncogenes which, when activated, become dominant events characterized by the gain of function, and tumor suppressor genes which become recessive events characterized by the loss of f