Molecular genetic evidence for common pathogenesis of childhood and adult Wilms' tumor
โ Scribed by Helen M. Kozman; Joanne M. Clarke; Melissa H. Little; Peter J. Smith
- Book ID
- 119104183
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 244 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
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Our objechves include: i) determirung correlations between Wilms' tumor-specific molecular genehc events and clinicopathologc features; (ii) identifyrig hrther DNA/chromosomal aberrations; and (iii) establishing a Wilms' tumor tissue bank. To this end, a Witms' tumor biology protocol has been develo
Several chromosomal regions exhibit loss of heterozygosity (LOH) in different types of human tumor, and on this basis are presumed to carry-suppressor genes. We studied 7 of such chromosome regions, including 3p, Sq, I I p, I3q, I7p, 18q and ZZq, using a selected set of DNA markers in 44 Wilms' tumo