Genetic approaches to understanding brai
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Muenke, Maximilian ;Cohen, M. Michael
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Article
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2000
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John Wiley and Sons
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English
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Holoprosencephaly (HPE) is the most common major developmental defect of the forebrain in humans. Clinical expression is variable, ranging from a small brain with a single cerebral ventricle and cyclopia to clinically unaffected carriers in familial HPE. Significant etiologic heterogeneity exists in