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Molecular genetic analysis of the Prader–Willi syndrome by using fluorescent multiplex PCR of the dinucleotide repeats on chromosome 15q11–q13

✍ Scribed by Myeong Jin Lee; Hisahide Nishio; Toshiro Nagai; Nobuhiko Okamoto; Tsuyoshi Yuki; Kimiaki Sumino


Book ID
117075689
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
120 KB
Volume
271
Category
Article
ISSN
0009-8981

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✍ Bärbel Dittrich; Wendy P. Robinson; Hans Knoblauch; Karin Buiting; Kerstin Schmi 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 247 KB

The Prader-Willi syndrome (PWS) and the Angelman syndrome (AS) are distinct genetic disorders that are caused by a deletion of chromosome region 15q11-13 or by uniparental disomy for chromosome 15. Whereas PWS results from the absence of a paternal copy of 15q11-13, the absence of a maternal copy of