Molecular forms of prostate-specific antigen and human kallikrein 2 (hK2) in urine are not clinically useful for early detection and staging of prostate cancer
✍ Scribed by Jürgen Pannek; Harry G. Rittenhouse; Cindy L. Evans; Judith A. Finlay; Debra J. Bruzek; Jennifer L. Cox; Daniel W. Chan; Eric N.P. Subong; Alan W. Partin
- Book ID
- 119486960
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 769 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0090-4295
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Molecular forms of prostate-specific antigen (PSA) improve the differentiation between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) in men with total PSA concentrations between 4 and 10 microg/l. To evaluate the diagnostic utility of free PSA (fPSA) and complexed PSA forms for identi
## BACKGROUND. Human prostate-specific antigen (PSA) and human kallikrein 2 (hK2) are expressed primarily by prostate epithelial cells. PSA and hK2 both exist as free protein and complexed with protease inhibitors (e.g., ␣1-antichymotrypsin, ACT) in serum. The expression of PSA and hK2 in LNCaP ce