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Molecular Features Associated with Polyamine Modulation of NMDA Receptors

โœ Scribed by Lewin, Anita H.; Sun, Guobin; Fudala, Louise; Navarro, Hernan; Zhou, Li-Ming; Popik, Piotr; Faynsteyn, Alexander; Skolnick, Phil

Book ID
111895124
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
121 KB
Volume
41
Category
Article
ISSN
0022-2623

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Recent work has shown that kynurenic acid and several quinoxaline derivatives act as non-competitive NMDA receptor antagonists by binding to the glycine site associated with this receptor. In this study, we have tested the effect of the most potent and selective of these compounds, 7-chlorokynurenic