Molecular Farming (Plant-Made Pharmaceuticals and Technical Proteins) || Chloroplast Derived Antibodies, Biopharmaceuticals and Edible Vaccines

✍ Scribed by Fischer, Rainer; Schillberg, Stefan

• Book ID: 120598889
• Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
• Year: 2005
• Tongue: German
• Weight: 289 KB
• Edition: 1
• Category: Article
• ISBN: 3527307869
• DOI: 10.1002/3527603638.ch8

✦ Synopsis

Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels.

Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.

PLANT PRODUCTION TECHNOLOGIES

• Efficent and reliable production of pharmaceuticals in alfalfa

  • Foreign protein expression using plant cell suspension and hairy root cultures

    • Novel sprouting technology for recombinant protein production

      • Monocot expression systems for molecular farming

        • The field evaluation of transgenic crops engineered to produce recombinant proteins

          • Plant viral expression vectors: history and new developments

PLANT-MADE PHARMACEUTICALS

• Production of pharmaceutical proteins in plants and plant cell suspension cultures

  • Chloroplast derived antibodies, biopharmaceuticals and edible vaccines

    • Plant-derived vaccines: progress and constraints

      • Production of secretory IgA in transgenic plants

TECHNICAL PROTEIN

• Production of spider silk proteins in transgenic tobacco and potato

  • Gene farming in pea under field conditions

PRODUCTION AND PRODUCT ISSUES

• Host plants, systems and expression strategies for molecular farming

  • Downstream processing of plant-derived recombinant therapeutic proteins

    • Glycosylation of plant-made pharmaceuticals

      • Biosafety aspects of molecular farming in plants

        • A top-down view of molecular farming from the pharmaceutical industry: requirements and expectations

          • The role of science and discourse in the application of the precautionary approach