✦ LIBER ✦

Molecular farming in plants: Oilseeds as vehicles for the production of pharmaceutical proteins

✍ Scribed by Joseph G. Boothe; Jillian A. Saponja; Dana L. Parmenter

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 177 KB
Volume: 42
Category: Article
ISSN: 0272-4391
DOI: 10.1002/(sici)1098-2299(199711/12)42:3/4<172::aid-ddr9>3.0.co;2-n

No coin nor oath required. For personal study only.

✦ Synopsis

The advantages and limitations of plant-based systems for the production of recombinant biopharmaceutical proteins are discussed in the context of other host production systems presently available. A novel approach for the purification of recombinant proteins expressed in oilseeds is described that is based on the targeting of these proteins to seed oil bodies. The utility of this approach is demonstrated by the purification of the anticoagulant protein hirudin, produced in seeds of Brassica napus. Drug Dev. Res. 42:172-181, 1997.

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