Molecular evolution of type VI intermediate filament proteins
✍ Scribed by Dominique Guérette; Paul A Khan; Pierre E Savard; Michel Vincent
- Book ID
- 115002222
- Publisher
- BioMed Central
- Year
- 2007
- Tongue
- English
- Weight
- 391 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2148
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Together with microtubules and actin microfilaments, approximately 11 nm wide intermediate filaments (IFs) constitute the integrated, dynamic filament network present in the cytoplasm of metazoan cells. This network is critically involved in division, motility and other cellular processes. While the
We report the cloning of an intermediate filament (IF) cDNA from the cephalochordate amphioxus that encodes a protein assignable to the type I keratin group. This is the first type I keratin reported from an invertebrate. Molecular phylogenetic analyses reveal that amphioxus also possesses a type II