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Molecular evidence of HTLV-1 intrafamilial transmission in a non-endemic area in Argentina

✍ Scribed by R. Gastaldello; K. Otsuki; M.G. Barbas; A.C.P. Vicente; S. Gallego

Book ID
102378612
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
113 KB
Volume
76
Category
Article
ISSN
0146-6615

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✦ Synopsis

In the North of Argentina, an endemic area for HTLV-1, intrafamilial transmission of this virus has been observed. The HTLV-1 status in 13 family members of a seropositive blood donor from the central region of Argentina (non-endemic area) was investigated. According to serological and molecular assays, four members of this family (the blood donor, the husband, a son, and a daughter-in-law) proved to be HTLV-1 positive. LTR, tax, and env sequences from the provirus infecting the family members were identical. This strongly suggests the intrafamilial transmission of the virus. This study demonstrated intrafamilial transmission of HTLV-1 in a non-endemic area of Argentina.

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Correlation of HTLV-1 Tax genetic divers
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✍ Alena Mayo IΓ±iguez; RenΓ© Gastaldello; Koko Otsuki; Marcos Balangero; Filipe Carv πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 72 KB

## Abstract The oncoprotein Tax was characterized genetically from a large cohort of human T‐cell lymphotropic virus type 1 (HTLV‐1) seropositive individuals from the most endemic region of HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV‐1 infection in Argentina, the pr