Molecular estimates for molar attraction constants

✍ Scribed by Arthur Cammarata; Suh Jen Yau

• Book ID: 102408011
• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 490 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610510

✦ Synopsis

A semiempirical method is developed by which molar attraction constants and cohesive energy densities (the Hildebrand-Scott solubility parameter 6) can be calculated for relatively nonpolar substances. In the simplest possible modification of the method, only molecular polarizabilities and molar volumes must be known to effect the calculation. Good agreement between the experimental and theoretical estimates is obtained. To illustrate the method, the cohesive energy densities are calculated for some drug agents and formulation constituents.

Keyphrases

Molar attraction constants-method of calculation for nonpolar substances 0 Cohesive energy density-method of calculation for nonpolar substances, values for some drugs and excipients 0 Molecular estimates-molar attraction constants, semiempirical method of calculation 0 Polarizability-used in calculating molar attraction constants