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Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC-associated familial predisposition to cancer

โœ Scribed by Y. Hirai; K. Banno; M. Suzuki; Y. Ichikawa; Y. Udagawa; K. Sugano; Y. Miki


Book ID
108584268
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
128 KB
Volume
99
Category
Article
ISSN
1347-9032

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Mutations in hMSH2 and hMLH1 genes were analyzed in patients from 11 Japanese families that had been diagnosed as carrying hereditary nonpolyposis colorectal cancer (HNPCC) by clinical examination. Germ line mutations of hMSH2 gene were identified in 5 independent families in which colorectal (87% o