𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP

✍ Scribed by Florastina Payton-Stewart; Norberta W. Schoene; Young S. Kim; Matthew E. Burow; Thomas E. Cleveland; Stephen M. Boue; Thomas T. Y. Wang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
240 KB
Volume
48
Category
Article
ISSN
0899-1987

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Glyceollins are soy‐derived phytoalexins that have been proposed to be candidate cancer preventive compounds. The effect of the glyceollins on prostate cancer is unknown. The present study examined the molecular effects of soy phytoalexin, glyceollins, on human prostate cancer cell LNCaP to further elucidate its potential effects on prostate cancer prevention. We found that the glyceollins inhibited LNCaP cell growth similar to that of the soy isoflavone genistein. The growth inhibitory effects of the glyceollins appeared to be due to an inhibition of G1/S progression and correlated with an up‐regulation of cyclin‐dependent kinase inhibitor 1 A and B mRNA and protein levels. By contrast, genistein only up‐regulates cyclin‐dependent kinase inhibitor 1A. In addition, glyceollin treatments led to down‐regulated mRNA levels for androgen responsive genes. In contrast to genistein, this effect of glyceollins on androgen responsive genes appeared to be mediated through modulation of an estrogen‐ but not androgen‐mediated pathway. Hence, the glyceollins exerted multiple effects on LNCaP cells that may be considered cancer preventive and the mechanisms of action appeared to be different from other soy‐derived phytochemicals. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Inhibitory effects of evodiamine on the
Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP
✍ Shu-Fen Kan; William J. Huang; Lie-Chwen Lin; Paulus S. Wang 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 563 KB

## Abstract Evodiamine, isolated from a Chinese herbal drug named Wu‐Chu‐Yu, possesses many biological functions. Recently, it has been reported that Wu‐Chu‐Yu exerts an antiproliferative effect on several cancers. Prostate carcinoma initially occurs as an androgen‐dependent tumor and is the second

Genistein, a soy isoflavone, induces glu
Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3
✍ Kazuhiro Suzuki; Hidekazu Koike; Hiroshi Matsui; Yoshihiro Ono; Masaru Hasumi; H 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 174 KB 👁 1 views

## Abstract Genistein is a major component of soybean isoflavone and has multiple functions resulting in antitumor effects. Prostate cancer is 1 of the targets for the preventive role of genistein. We examined the effect of genistein on human prostate cancer (LNCaP and PC‐3) cells. Proliferation of

Enterolactone restricts the proliferatio
Enterolactone restricts the proliferation of the LNCaP human prostate cancer cell line in vitro
✍ Mark J. McCann; Chris I. R. Gill; Trevor Linton; D. Berrar; Hugh McGlynn; Ian R. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 550 KB

## Abstract Ecological data suggest a long‐term diet high in plant material rich in biologically active compounds, such as the lignans, can significantly influence the development of prostate cancer over the lifetime of an individual. The capacity of a pure mammalian lignan, enterolactone (ENL), to

Induction of apoptosis by mifepristone a
Induction of apoptosis by mifepristone and tamoxifen in human LNCaP prostate cancer cells in culture
✍ El Etreby, M. Fathy; Liang, Yayun; Lewis, Ronald W. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB 👁 2 views

data indicate that antiprogestins and antiestrogens could inhibit prostate cancer cell growth in vitro and in vivo. The main objective of the present studies was to explore the role of bcl 2 and TGF␤ 1 for induction of apoptosis in LNCaP prostate cancer cells growing in culture as a treatment respon

Inhibition of prostaglandin synthesis an
Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients
✍ Srilatha Swami; Aruna V. Krishnan; Jacqueline Moreno; Rumi S. Bhattacharyya; Chr 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 513 KB

## Abstract Soy and its constituent isoflavone genistein inhibit the development and progression of prostate cancer (PCa). Our study in both cultured cells and PCa patients reveals a novel pathway for the actions of genistein, namely the inhibition of the synthesis and biological actions of prostag

Studies of rhodamine-123: Effect on rat
Studies of rhodamine-123: Effect on rat prostate cancer and human prostate cancer cells in vitro
✍ John A. Arcadi; K. Shankar Narayan; Geza Techy; Chuen-Pei Ng; Ramez M. G. Sarouf 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 860 KB

## Abstract The effect of the lipophilic, cationic dye, Rhodamine‐123 (Rh‐123), on prostate cancer in rats, and on three tumor cell lines in vitro is reported here. The general toxicity of Rh‐123 in mice has been found to be minimal. Lobund‐Wistar (L‐W) rats with the autochthonous prostate cancer o