✦ LIBER ✦

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity

✍ Scribed by Björn Windshügel; Johanna Jyrkkärinne; Antti Poso; Paavo Honkakoski; Wolfgang Sippl

Publisher: Springer-Verlag
Year: 2004
Tongue: English
Weight: 1020 KB
Volume: 11
Category: Article
ISSN: 1610-2940
DOI: 10.1007/s00894-004-0227-4

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Constitutive activity and ligand-depende

Constitutive activity and ligand-dependent activation of the nuclear receptor CAR—insights from molecular dynamics simulations

✍ Björn Windshügel; Antti Poso 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 434 KB

## Abstract The constitutive androstane receptor (CAR) possesses, unlike most other nuclear receptors, a pronounced basal activity __in vitro__ whose structural basis is still not fully understood. Using comparative molecular dynamics simulations of CAR X‐ray crystal structures, we evaluated the mo

Ligand-escape pathways from the ligand-b

Ligand-escape pathways from the ligand-binding domain of PPARγ receptor as probed by molecular dynamics simulations

✍ D. Genest; N. Garnier; A. Arrault; C. Marot; L. Morin-Allory; M. Genest 📂 Article 📅 2007 🏛 Springer 🌐 English ⚖ 497 KB

Recognition of LXXLL by Ligand Binding D

Recognition of LXXLL by Ligand Binding Domain of the Farnesoid X Receptor in Molecular Dynamics Simulation.

✍ Tao Zhang; Xi-Cheng Dong; Min-Bo Chen 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 11 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Differential recognition of resveratrol

Differential recognition of resveratrol isomers by the human estrogen receptor-α: Molecular dynamics evidence for stereoselective ligand binding

✍ Laila A. Abou-Zeid; Abdalla M. El-Mowafy 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

Molecular characterization of the chemok

Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation

✍ Georgina Xanthou; Timothy J. Williams; James E. Pease 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 289 KB 👁 1 views

Analysis of interactions responsible for

Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors—molecular dynamics study of the activated receptor–vasopressin–Gα systems

✍ Magdalena J. Ślusarz; Artur Giełdoń; Rafał Ślusarz; Jerzy Ciarkowski 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 789 KB

Vasopressin (CYFQNCPRG-NH(2), AVP) is a semicyclic endogenous peptide, which exerts a variety of biological effects in mammals. The main physiological roles of AVP are the regulation of water balance and the control of blood pressure and adrenocorticotropin hormone (ACTH) secretion, mediated via thr