Behavior of the ATP grasp domain of biot
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Brian R. Novak; Dorel Moldovan; Grover L. Waldrop; Marcio S. de Queiroz
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Article
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2010
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John Wiley and Sons
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English
β 630 KB
The enzyme biotin carboxylase (BC) uses adenosine triphosphate (ATP) to carboxylate biotin and is involved in fatty acid synthesis. Structural evidence suggests that the B domain of BC undergoes a large hinge motion of βΌ45Β° when binding and releasing substrates. Escherichia coli BC can function as a