Molecular dynamics simulations of atomic-level brittle fracture mechanisms in amorphous silica

Mechanisms of constitutive activation of

Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations

✍ Tai-Sung Lee; Wanlong Ma; Xi Zhang; Francis Giles; Hagop Kantarjian; Maher Albit 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 911 KB

## Abstract ## BACKGROUND: The tyrosine kinase Janus kinase 2 (JAK2) is important in triggering nuclear translocation and regulation of target genes expression through signal transducer and activator of transcription pathways. The valine‐to‐phenylalanine mutation at amino acid 617 (V617F), which r