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Molecular dynamics simulations and binding free energy analysis of DNA minor groove complexes of curcumin

✍ Scribed by Mathew Varghese Koonammackal; Unnikrishnan Viswambharan Nair Nellipparambil; Chellappanpillai Sudarsanakumar


Book ID
106240488
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
610 KB
Volume
17
Category
Article
ISSN
1610-2940

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Recognition of Ras by its downstream target Raf is mediated by a Rasrecognition region in the Ras-binding domain (RBD) of Raf. Residues 78-89 in this region occupy two different conformations in the ensemble of NMR solution structures of the RBD: a fully ␣-helical one, and one where 87-90 form a typ