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Molecular dynamics simulation of cyclodextrin inclusion complexes in enzymatic lipid hydrolysis

✍ Scribed by Györgyi J. Kolossváry; István Kolossváry

Publisher
Springer Netherlands
Year
1996
Tongue
English
Weight
623 KB
Volume
18
Category
Article
ISSN
0141-5492

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✦ Synopsis

Cyclodextrin derivatives can increase the enzymatic hydrolysis of triolein in aqueous solution. Two types of cyclodextrin inclusion complexes could be responsible for this effect. In the present study, molecular dynamics simulations clearly suggest that cyclodextrin hosts only the liberated fatty acid thus accelerating lipolysis by decreasing product inhibition.

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