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Molecular Dynamics and Free Energy Study of the Conformational Equilibria in the UUUU RNA Hairpin

✍ Scribed by Deng, Nan-Jie; Cieplak, Piotr


Book ID
125509157
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
894 KB
Volume
3
Category
Article
ISSN
1549-9618

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Recognition of Ras by its downstream target Raf is mediated by a Rasrecognition region in the Ras-binding domain (RBD) of Raf. Residues 78-89 in this region occupy two different conformations in the ensemble of NMR solution structures of the RBD: a fully ␣-helical one, and one where 87-90 form a typ