The excretion of emtricitabine (FTC) was characterized using isolated perfused rat kidney (IPK) model. Studies were performed to assess the dose-linearity of FTC excretion, to evaluate the effect of inhibitors of organic anion (probenecid, PBC), organic cation (tetraethylammonium, TEA; cimetidine, C
โฆ LIBER โฆ
Molecular Diversity of Organic Cation Transporter (OCT) Mediating Renal Excretion of Drugs
โ Scribed by Yumiko Urakami
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 52 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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The human organic cation transporter 2 (OCT2, SLC22A2) is a multispecific transporter of organic cations, including many clinically used drugs. OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is considered a major