Molecular Diagnostics || An Historical Perspective on the Clinical Diagnostic Laboratory
β Scribed by Coleman, William B.; Tsongalis, Gregory J.
- Book ID
- 120190954
- Publisher
- Humana Press
- Year
- 2006
- Weight
- 267 KB
- Category
- Article
- ISBN
- 1592599281
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## Abstract The Philadelphia (Ph) chromosome is characteristic of chronic myelogenous leukemia (CML), but it is also the most frequent cytogenetic abnormality in precursor Bβlymphoblastic leukemia (ALL) of adults. The vast majority of CML patients have a BCRβABL translocation that yields a 210 kD (
## Communicated by Arthur L. Beaudet We devised a set of allele-specific probes to detect simultaneously 3 1 known cystic fibrosis mutations using PCR and the reverse dot blot detection format. The assay has been implemented in a clinical setting to the screening of over 750 individuals. Of these