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Molecular diagnosis of X-linked chronic granulomatous disease in Iran

✍ Scribed by S. Teimourian; Z. Rezvani; M. Badalzadeh; C. Kannengiesser; D. Mansouri; M. Movahedi; E. Zomorodian; N. Parvaneh; S. Mamishi; Z. Pourpak; M. Moin


Book ID
107618513
Publisher
Carden Jennings Publishing
Year
2008
Tongue
English
Weight
264 KB
Volume
87
Category
Article
ISSN
0925-5710

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The most frequent form of chronic granulomatous disease (CGD) is caused by inactivation of the CYBB gene, which encodes the gp91-phox subunit of phagocyte NADPH oxidase. This defect prevents phagocytes from producing reactive oxygen species and thus from eradicating bacterial and fungal infections.