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Molecular diagnosis of X-linked agammaglobulinaemia

✍ Scribed by I. Vorechkovsky; J.-N. Zhou; D. Vetrie; D. Bentley; J. Björkander; L. Hammarström; C.I.E. Smith

Book ID
119067388
Publisher
The Lancet
Year
1993
Tongue
English
Weight
163 KB
Volume
341
Category
Article
ISSN
0140-6736

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The genetic transmission of X-linked agammaglobulinaemia (XLA) can be determined with high probability using closely linked DNA restriction fragment length polymorphisms (RFLP's). In a family known to be at risk for XLA in male offspring, RFLP analysis demonstrated that the mother was an XLA carrier