✦ LIBER ✦

Molecular determination of the malignant potential of smooth muscle neoplasms

✍ Scribed by Wendy Trzyna; Mary McHugh; Peter McCue; Kirk M. McHugh

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 525 KB
Volume: 80
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19970715)80:2<211::aid-cncr7>3.0.co;2-w

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

The determination of the malignant potential of smooth muscle neoplasms remains ambiguous, and yet has far reaching clinical, therapeutic, and social implications.

Methods:

In this pilot study, the authors examined smooth muscle isoactin gene expression by polymerase chain reaction in a variety of smooth muscle tumors.

Results:

A lack of gamma-smooth muscle isoactin gene expression correlated 100% with a pathologic diagnosis of sarcoma. these results suggest that gamma-smooth muscle isoactin gene expression represents a unique molecular marker of oncogenic transformation.

Conclusions:

Gamma-smooth muscle isoactin gene expression provides a valuable molecular adjunct to the diagnosis of smooth muscle neoplasms.

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