✦ LIBER ✦

Molecular determinants of tumor differentiation in papillary serous ovarian carcinoma

✍ Scribed by Amir A. Jazaeri; Karen Lu; Rosemarie Schmandt; Charles P. Harris; Pulivarthi H. Rao; Christos Sotiriou; G. V. R. Chandramouli; David M. Gershenson; Edison T. Liu

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 225 KB
Volume: 36
Category: Article
ISSN: 0899-1987
DOI: 10.1002/mc.10098

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In epithelial ovarian cancer, tumor grade is an independent prognosticator whose molecular determinants remain unknown. We investigated patterns of gene expression in well‐ and poorly differentiated serous papillary ovarian and peritoneal carcinomas with cDNA microarrays. A 6500‐feature cDNA microarray was used for comparison of the molecular profiles of eight grade III and four grade I stage III serous papillary adenocarcinomas. With a modified F‐test in conjunction with random permutations, 99 genes whose expression was significantly different between grade I and grade III tumors were identified (P < 0.01). A disproportionate number of these differentially expressed genes were located on the chromosomal regions 20q13 and all exhibited higher expression in grade III tumors. Interphase fluorescent in situ hybridization demonstrated 20q13 amplification in two of the four grade III and none of the three grade I tumors available for evaluation. Several centrosome‐related genes also showed higher expression in grade III tumors. We propose a model in which tumor differentiation is inversely correlated with the overexpression of several oncogenes located on 20q13, a common amplicon in ovarian and numerous other cancers. Dysregulation of centrosome function is one potential mechanistic link between genetic/epigenetic changes and the poorly differentiated phenotype in ovarian cancer. Published 2003 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Gene expression profiles in primary ovar

Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: Identification of candidate molecular markers for ovarian cancer diagnosis and therapy

✍ Alessandro D. Santin; Fenghuang Zhan; Stefania Bellone; Michela Palmieri; Stefan 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 550 KB

## Abstract With the goal of identifying genes with a differential pattern of expression between ovarian serous papillary carcinomas (OSPCs) and normal ovarian (NOVA) epithelium and using this knowledge for the development of novel diagnostic and therapeutic markers for ovarian cancer, we used olig

Ovarian papillary serous tumors of low m

Ovarian papillary serous tumors of low malignant potential (Serous borderline tumors): A long term follow-up study, including patients with microinvasion, lymph node metastasis, and transformation to invasive serous carcinoma

✍ Alexander W. Kennedy; William R. Hart 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 900 KB

## Background: The clinical outcome of patients with ovarian serous tumors of low malignant potential (lmp) remains controversial, especially for those with extraovarian disease. we retrospectively reviewed our experience to study this question further, to assess the safety of conservative manageme

The effect of cyclooxygenase-2 expressio

The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma

✍ Rouba Ali-Fehmi; Mingxin Che; Ibrahim Khalifeh; John M. Malone; Robert Morris; W 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 335 KB

## Abstract ## BACKGROUND Cyclooxygenase‐2 (COX‐2) seems to be involved at various steps in the processes of malignant transformation and tumor progression. Investigations have shown that COX‐2 overexpression is associated with increased proliferation, reduced apoptosis, and angiogenesis. ## METH

Influence of tumor grade on expression o

Influence of tumor grade on expression of CA 125 in serum and tissue in patients with serous ovarian carcinoma

✍ Igor But 📂 Article 📅 2003 🏛 Springer Vienna 🌐 English ⚖ 490 KB

Evaluation of PAS-diastase and carcinoem

Evaluation of PAS-diastase and carcinoembryonic antigen staining in the differential diagnosis of malignant mesothelioma and papillary serous carcinoma of the ovary

✍ Paul B. Silcocks; Amanda Herbert; Dennis H. Wright 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 806 KB

Low-molecular weight forms of cyclin E d

Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma

✍ Ben Davidson; Martina Skrede; Ilvars Silins; Ie-Ming Shih; Claes G. Trope; Vivi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 232 KB 👁 1 views

## Abstract ## BACKGROUND. The authors recently reported on the role of cyclin E in differentiating ovarian/primary peritoneal carcinoma from malignant peritoneal mesothelioma using gene expression arrays. In the current study, they analyzed the expression of low‐molecular weight (LMW) forms of cy