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Molecular Determinants of the Anticonvulsant Felbamate Binding Site in the N -Methyl- d -Aspartate Receptor

โœ Scribed by Chang, Huai-Ren; Kuo, Chung-Chin

Book ID
127253913
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
830 KB
Volume
51
Category
Article
ISSN
0022-2623

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The novel anticonvulsant MK-801 binds to
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โœ Alan C. Foster; Erik H.F. Wong ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 1022 KB

The influence of endogenous and exogenous acidic amino acids on the binding of [3H]-MK-801, a selective, non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has been inves- tigated in rat cerebral cortex crude synaptic membranes (CSM). 2 Removal of endogenous glutamate and aspartate