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Molecular determinants of neural crest migration

✍ Scribed by Maschhoff, Kathryn L. ;Baldwin, H. Scott

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 246 KB
Volume: 97
Category: Article
ISSN: 0148-7299
DOI: 10.1002/1096-8628(200024)97:4<280::aid-ajmg1278>3.0.co;2-n

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✦ Synopsis

Normal septation of the cardiac out¯ow tract requires migration of neural crest cells from the posterior rhombencephalon to the branchial arches and developing conotruncal endocardial cushions. Proper migration of these cells is mediated by a variety of molecular cues. Adhesion molecules, such as integrins, are involved in the interaction of neural crest cells with the extracellular matrix, while cadherins allow neural crest cells to interact with each other during their migration. Pax3 appears to be important for proliferation of neural crest precursors, and connexin-43-mediated gap junction communication in¯uences the rate of migration. Endothelin and its receptors are required for normal postmigratory differentiation. Platelet-derived growth factor and retinoic acid have roles in neural crest migration and differentiation as well. Finally, the similarity between the cardiovascular malformations seen in the DiGeorge and 22q11 deletion syndromes and animal models of neural crest de®ciency has led to the examination of the role of genes located near or within the DiGeorge critical region in neural crest migration. Am.

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