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Molecular details of anesthetic-lipid interaction as seen by deuterium and phosphorus-31 nuclear magnetic resonance

โœ Scribed by Boulanger, Yvan; Schreier, Shirley; Smith, Ian C. P.


Book ID
126023595
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
775 KB
Volume
20
Category
Article
ISSN
0006-2960

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Cyclosporin A (CyA) interacts with lipid membranes. Binding reaction and membrane location of CyA and analogs were examined with 2 H-NMR, high-sensitivity isothermal titration calorimetry (ITC), and CD spectroscopy. Effects of CyA and charged analogs on the phosphocholine head group and on the membr