Molecular Design of Specific Metal-Binding Peptide Sequences from Protein Fragments: Theory and Experiment

Molecular dynamics simulation and automa

Molecular dynamics simulation and automated docking of the pro-apoptotic bax protein and its complex with a peptide designed from the Bax-binding domain of anti-apoptotic Ku70

✍ Fabrizio Mancinelli; Michele Caraglia; Alfredo Budillon; Alberto Abbruzzese; Ett 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 399 KB

## Abstract Bax, a multi‐domain protein belonging to the large family of Bcl‐2 proteins, has a pivotal role for the initiation of the cytochrome __c__‐mediated apoptosis, a vital physiologic process to eliminate damaged or unwanted cells. In response to specific stimuli Bax translocates from cytoso