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Molecular design of biodegradable polymeric micelles for temperature-responsive drug release

✍ Scribed by Masamichi Nakayama; Teruo Okano; Takanari Miyazaki; Fukashi Kohori; Kiyotaka Sakai; Masayuki Yokoyama

Book ID
113691302
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
470 KB
Volume
115
Category
Article
ISSN
0168-3659

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## Abstract A new controlled release polymer micelle was designed and synthesized based on the concept of the β€œAND” logic with two orthogonal molecular triggers, namely pH and reduction, for intracellular drug delivery. Specifically, a hydrazine functionalized PEO‐__b__‐PMAA block copolymer was use