A deletion of the long arm of chromosome 20 [del(20q)] is a recurring abnormality in a wide spectrum of myeloid disorders. Loss of genetic material from 20q may confer a proliferative advantage to myeloid cells, possibly through loss of function of a tumor suppressor gene. Previously, we analyzed le
Molecular delineation of the commonly deleted segment in mature B-cell lymphoid neoplasias with deletion of 7q
✍ Scribed by Jesús María Hernández; Eric F. P. M. Schoenmakers; Paola Dal Cin; Lucienne Michaux; Wim J. M. Van de Ven; Herman Van den Berghe
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 57 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
FISH, using 16 probes, informative for more than 30 different loci, allowed us better to delineate the common deleted region in mature B-cell lymphoid malignancies with deletions of chromosome 7. The region spans about 5 cM and is located between bands 7q31 and 7q32, between loci D7S685 and D7S514.
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