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Molecular Definition of Interstitial Deletions of Chromosome 13 in Leukemic Cells

✍ Scribed by Christine M. Morris; Jill M. Cochrane; Suzanne M. Benjes; Peter E. Crossen; Peter H. Fitzgerald

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
823 KB
Volume
3
Category
Article
ISSN
1045-2257

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✦ Synopsis

Three patients with leukemia and one with a myeloproliferative disorder carried an interstitial deletion of chromosome 13, del( I3)(q 12q 14). in leukemic cells. Proximal and distal breakpoints of the deleted segment were characterized by using DNA restriction fragment length polymorphisms of chromosome I3 supplemented by quantitative densitometry of hybridization signals to determine the copy number of individual loci. Both proximal and distal breakpoints varied between patients, and it is unlikely that a significant hybrid gene was formed by rejoining at the breakpoint junctions. The retinoblastoma gene was encompassed by the deleted segment in all four patients.

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