Molecular cytogenetic techniques for the diagnosis of chromosomal abnormalities in childhood disease
✍ Scribed by M. Stumm; H. Tönnies; P. F. Wieacker
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 254 KB
- Volume
- 158
- Category
- Article
- ISSN
- 0340-6997
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## Background: The authors have determined the prognostic significance of cytogenetically detectable 12p abnormalities, which are frequent in children with acute lymphoblastic leukemia (all), in a large cohort of patients treated on risk-adjusted protocols of the children's cancer group (ccg). ##
Monozygotic twins discordant for the Wiedemann-Beckwith syndrome (WBS) were studied by cytogenetic and molecular methods to determine if a genetic lesion could be detected in the affected child. Probes known to be localized on the short arm of chromosome 11 and a low copy-repetitive probe were used.
To the Editor: Hb S (6 Glu-Val), Hb D Los Angeles (121 Glu-Gln) and Hb O Arab (121 Glu-Lys) are the most common variants in Turkish population including Turkish Cypriots [1,2]. Either during screening of the population or to enlighten the reason of anemia; several abnormal hemoglobin variants can