✦ LIBER ✦

Molecular cytogenetic resources specific for chromosome 12

✍ Scribed by Viggiano, Luigi; Miolla, Valeria; Ricco, Angela; Storlazzi, Clelia Tiziana; Pennacchia, Margherita; Fratello, Angelo; Mancini, Mita; Marzella, Rosalia; Archidiacono, Nicoletta; Rocchi, Mariano

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 50 KB
Volume: 87
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19991105)87:1<40::aid-ajmg8>3.0.co;2-2

No coin nor oath required. For personal study only.

✦ Synopsis

We have generated a panel of 20 somatic cell hybrids retaining fragments of human chromosome 12. Each hybrid was characterized cytogenetically by reverse fluorescence in situ hybridization (FISH) and molecularly by 24 sequence tagged sites (STSs) spaced evenly along the chromosome. The panel can be exploited to map subregionally DNA sequences on chromosome 12 and to generate partial chromosome paints useful in the characterization of chromosomal rearrangements involving this chromosome. Furthermore, a panel of 58 yeast artificial chromosomes (YACs) mapping to chromosome 12 was characterized by FISH experiments on normal human metaphases. A subset of this panel is recognized by the STSs used in the somatic cell hybrid characterization. In this way a correlation between the genetic and the physical maps of this chromosome can be established. Am. J. Med. Genet. 87:40-44, 1999.

📜 SIMILAR VOLUMES

Cytogenetic and molecular evidence for c

Cytogenetic and molecular evidence for cutaneous mosaicism: The ectodermal origin of Blaschko lines

✍ Moss, Celia 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 16 KB 👁 2 views

The idea that skin disorders following Blaschko lines represent genetic mosaicism is widely accepted. It seems likely that the two skin types represent the two different genotypes, but this has been remarkably difficult to prove, most studies showing a mixture of cell types in biopsies from both typ

Chromosomes 12 and 16 workshop

✍ Detera-Wadleigh, Sevilla D.; Barden, N.; Craddock, N.; Ewald, H.; Foroud, T.; Ke 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 24 KB 👁 2 views

Recent linkage results independently derived from a large French Canadian pedigree and Danish kindreds coupled with supportive data from other studies provide compelling evidence for a bipolar disorder susceptibility locus on chromosome 12q23-q24. The idea is further strengthened by the finding that

Molecular cytogenetics of a de novo inte

Molecular cytogenetics of a de novo interstitial deletion of chromosome arm 6q in a developmentally normal girl

✍ Kumar, Arun; Cassidy, Suzanne B.; Romero, Lynne; Schwartz, Stuart 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 35 KB 👁 2 views

Using fluorescence in situ hybridization and microsatellite analysis, we have characterized a de novo interstitial deletion on the long arm of chromosome 6 [46,XX,del(6) (q23.3q24.2)] in a developmentally normal girl with very mild phenotypic abnormalities. The deletion was paternal in origin and wa

Subhuman Resources

✍ Gary Jonas; Rebecca Hodgkins 📂 Fiction 📅 2016 🏛 Denton & White 🌐 English ⚖ 132 KB 👁 2 views

**KIDNAPPED!** When Kelly's favorite student disappears under mysterious circumstances, the magically engineered assassin is drawn into a conspiracy involving vampires, ghouls, and her former employer and creator, Dragon Gate Industries. **A TERRIBLE EXPERIMENT** DGI is creating an army capable o

Inhuman Resources

✍ Gordon, Sam;Lemaître, Pierre 📂 Fiction 📅 2018 🏛 Quercus 🌐 en-US ⚖ 219 KB 👁 1 views

**When Alain Delambre lost his job four years ago, he lost everything. Now he's breaking all the rules for one last shot at the life he thinks he deserves.** ** ** **"Lemaitre has dared everything here."_Le Parisien_** ** _ _** **"A really excellent suspense novelist." Stephen King**

Cytogenetic and molecular analysis of in

Cytogenetic and molecular analysis of inv dup(15) chromosomes observed in two patients with autistic disorder and mental retardation

✍ Flejter, Wendy L.; Bennett-Baker, Pamela E.; Ghaziuddin, Mohammad; McDonald, Mar 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 18 KB 👁 1 views

A variety of distinct phenotypes has been associated with supernumerary inv dup( 15) chromosomes. Although different cytogenetic rearrangements have been associated with distinguishable clinical syndromes, precise genotype-phenotype correlations have not been determined. However, the availability of