𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Molecular-cytogenetic comparison of mucosa-associated marginal zone B-cell lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract

✍ Scribed by Thomas F.E. Barth; Martin Bentz; Frank Leithäuser; Stephan Stilgenbauer; Reiner Siebert; Magdalena Schlotter; Richard F. Schlenk; Hartmut Döhner; Peter Möller

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
345 KB
Volume
31
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Extranodal B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT) type may represent a model of lymphoma progression, because a small cell component frequently occurs in the large cell variants. We studied 52 extranodal B‐cell lymphomas: 18 extranodal marginal zone B‐cell lymphomas of MALT type (MZBL,MT), 7 MZBL,MT of the gastro‐intestinal tract with a diffuse large B‐cell component (giMZBL__plus__LBCL), and 27 diffuse large B‐cell lymphomas of the gastro‐intestinal tract without small cell component (giLBCL). Analytical techniques were comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH). The translocation t(11;18) was found as the sole aberration in two MZBL,MT only. In contrast to this, t(11;18)‐negative MZBL,MT were characterized by frequent gains on chromosome 3 and DNA amplifications on 2p13–p15. Furthermore, we found a clonal lymphoma progression from the small to the large cell component with accumulation of gains and losses of chromosomal material in the large cell component in giMZBL__plus__LBCL. Aberrations overlapping with MZBL,MT and giMZBL__plus__LBCL included losses on chromosome 13, amplifications of the REL proto‐oncogene, or gains on chromosome 12. In addition, the large cell component revealed gains on 8q24, including amplifications of the MYC proto‐oncogene, and losses on 2q. The giLBCL had frequent gains on chromosomes 12 and 9, as well as on 11q, and losses on 6q. We conclude that, based on the distinctive and partly overlapping patterns of genetic aberrations, MALT lymphomas can be divided into different genetic subgroups. © 2001 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Molecular cytogenetic delineation of the
Molecular cytogenetic delineation of the breakpoint at 18q21.1 in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue
✍ Tomoaki Akagi; Akiko Tamura; Mutsuhito Motegi; Ritsuro Suzuki; Yoshitaka Hosokaw 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 447 KB 👁 1 views

Extranodal malignant non-Hodgkin lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma) represents a subtype of B-cell lymphoid malignancies with distinct clinicopathological features and is often associated with a favorable prognosis. Recent cytogenetic studies have revealed that t(11;1

Extranodal marginal zone B-cell lymphoma
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of the head and neck area : High rate of disease recurrence following local therapy
✍ Catharina Wenzel; Wolfgang Fiebiger; Karin Dieckmann; Michael Formanek; Andreas 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB

## Abstract ## BACKGROUND Mucosa‐associated lymphoid tissue (MALT) lymphoma is a distinct entity with specific clinical and pathologic features that may affect diverse organs. MALT–lymphomas remain localized within their original environment for a long period of time. As recent data have demonstra

Radiotherapy for extranodal, marginal zo
Radiotherapy for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue originating in the ocular adnexa : A multiinstitutional, retrospective review of 50 patients
✍ Takashi Uno; Koichi Isobe; Naoto Shikama; Atsushi Nishikawa; Masahiko Oguchi; Na 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB 👁 1 views

## Abstract ## BACKGROUND Due to the small number of patients and differences in the pathologic classification in most radiotherapy series, information regarding the adequacy of tumor control in patients with ocular‐adnexal marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT l