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Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14)

✍ Scribed by Hege Vangstein Aamot; Geir E. Tjønnfjord; Jan Delabie; Sverre Heim


Book ID
113512809
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
141 KB
Volume
165
Category
Article
ISSN
0165-4608

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Detection of t(11;14) using interphase m
✍ Hervé Avet-Loiseau; Richard Garand; Fanny Gaillard; Axelle Daviet; Marie-Paule M 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 2 views

The chromosomal translocation t(11;14)(q13;q32) fuses the IGH and CCND1 genes and leads to cyclin D1 overexpression. This genetic abnormality is the hallmark of mantle cell lymphoma (MCL), but is also found in some cases of atypical chronic lymphocytic leukemia (CLL), characterized by a poor outcome