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Molecular cytogenetic analysis of a human breast metastasis model: identification of phenotype-specific chromosomal rearrangements

✍ Scribed by Steve Goodison; Carrie Viars; Virginia Urquidi

Book ID
113512486
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
517 KB
Volume
156
Category
Article
ISSN
0165-4608

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Molecular cytogenetic analysis of a nont
Molecular cytogenetic analysis of a nontumorigenic human breast epithelial cell line that eventually turns tumorigenic: Validation of an analytical approach combining karyotyping, comparative genomic hybridization, chromosome painting, and single-locus fluorescence in situ hybridization
✍ Kirsten Vang Nielsen; Erik Niebuhr; Bent Ejlertsen; SΓΈren Holstebroe; Mogens Win πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 219 KB πŸ‘ 2 views

The immortalized, nontumorigenic human breast epithelial cell line HMT-3522 has been used as a model for premalignant and, eventually, malignant development. During cultivation, the karyotype evolution was followed. At an early stage, a very long constant phase showed a near-diploid karyotype, with